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Clopidogrel Trial

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Posted 04/01/10

Migraine Action member Elaine Lee got in touch as she wanted to share her experience of taking part in a trial for use of the drug Clopidogrel as a prophylactic treatment for migraine.

Elaine has suffered from migraine for many years and has tried different prophylactic treatments in the past to no avail.

She discovered that Professor Chambers, a consultant cardiologist, at Guy's and St Thomas' Hospital, London was conducting a trial into the use of Clopidogrel as a prophylactic treatment for migraine (the drug is commonly given to patients after heart surgery).

Elaine started the trial in June, having completed a headache diary for a month prior to this. Elaine is convinced that the drug has worked for her. She found that she has only had one migraine in the six months since the trial started when she had a break from Clopidogrel whilst waiting for a prescription. Elaine says: "I cannot put into words what a massive impact on my physical and psychological wellbeing that taking Clopidogrel has had on my life."

Elaine is currently discussing with her GP whether she can continue to take the drug now that the trial has ended, as it is not as yet licensed for migraine prophylaxis. (Doctors may decide to wait until the results of the trial are analysed or until such time as the official licence allows Clopidogrel for migraine).

Participants on the trial are recognised by their doctor as having between 4 - 15 days of migraine headache everyone month. During the trial they undergo a blood test, are asked to keep a headache diary prior to, during and after the trial and also have an ultrasound scan of the heart (echocardiogram) to check for a possible patent foramen ovale (flap between the atria of the heart).  The whole study usually takes around four months and involves four visits to meet the study nurse. Participants will either be given the drug or a placebo pill.

Anyone who is interested in being considered for participation in the trial can contact Elaine Wong, Research Sister at the hospital for further information on 020 7188 7188 (ext 51235 or 80941) or leave a message on the answer phone (020 7188 0726) or can get in touch via email - Elaine.Wong@gstt.nhs.uk

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